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| UDK 616.61-002.52-091.8 |
ISSN 0350-2899, 36(2011) br.1 p.48-55 |
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Literature review Diagnostics and therapy of lupus nephritis (Dijagnoza i lečenje lupus nefritisa) Aleksandra Nikolić (1), Dejan Petrović (2), Biserka Tirmenštajn Janković (3), Milenko Živanović (3), Mirjana Veselinović (4), Biljana Stojimirović (5) (1) Klinički centar "Kragujevac", Klinika za internu medicinu, Odsek za alergologiju sa kliničkom imunologijom, (2) Klinički centar "Kragujevac", Klinika za urologiju i nefrologiju, Centar za nefrologiju i dijalizu, (3) Zdravstveni centar "Zaječar", Odeljenje za hemodijalizu, (4) Klinički centar "Kragujevac", Klinika za internu medicinu, Odsek reumatologije, (5) Klinički centar Srbije, Beograd, Klinika za nefrologiju |
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| Summary: Systemic Lupus Erythematosus - SLE is a systemic autoimmune disease of unclear etiology, characterized by numerous immune disorders. Genetic factors, gender, race, immune system disorder, infective agents and medicaments all play important roles in the pathogenesis of the disease. Systemic lupus erythematosus can show various symptoms such as skin and joints problems, serosis, central nervous system disorder and kidney failure. The disease is diagnosed by using ACR criteria (American College of Rheumatology). Lupus nephritis is the main cause of morbidity and mortality among patients with systemic lupus erythematosus. DNA-anti-DNA-antibody immuno-complexes play an important role in pathogenesis of systemic lupus erythematosus and lupus nephritis. A high level of anti-dsDNA-anibody, anti-Sm-antibody and anti-C1q-antybody with great preciseness indicate the development of lupus nephritis in patients with systemic lupus erythematosus. The use of aggressive immunosuppressive therapy increases the chances for saving both the kidneys and the life of patients with systemic lupus erythematosus. Modern treatments should enable better remission of the disease and smaller citotoxicology when compared to standard, conventional therapy. Early detection of systemic lupus erythematosus and lupus nephritis should lead to timely application of adequate therapy, and should also prevent further progression of the disease and development of the final stages of chronic kidney failure, help decrease morbidity and mortality and improve the quality of life for patients with this disease. Key words: systemic lupus erythematosus, lupus nephritis, immunosuppressive therapy Napomena:
kompletan tekst rada na srpskom jeziku |
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Corresponding Address: Aleksandra Nikolić Zmaj Jovina 30, 34000 Kragujevac e-mail: sandra68@eunet.rs |
Paper
received: 13.02.2011 Paper accepted: 20.03.2011 Paper Internet issues: 20.06.2011 |
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