Journal of Regional Section of Serbian Medical Association in Zajecar

Year 2014     Vol 39     No 4
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      UDK 616.441-006.6-08

ISSN 035-2899, 39(2014) br.4 p.176-183

Original paper

The role of stimulated tireoglobulin in the management of patients with differentiated thyroid carcinoma
(Značaj određivanja stimulisanog tireoglobulina u lečenju pacijenta sa diferentovanim tireoidnim karcinomom)

Marina Vlajković (1), Milena Rajić (1), Slobodan Ilić (1), Miloš Stević (1), Mila Zečević (1), Aleksandar Karanikolić (2), Radan Džodić (3), Milovan Matović (4), Vera Artiko (5)
(1) Centar za nuklearnu medicinu, Klinički centar Niš, (2) Klinika za opštu hirurgiju, Klinički centar Niš, (3) Institut za onkologiju i radiologiju Srbije, KC Srbije, (4) Centar za nuklearnu medicinu, Klinički centar Kragujevac, (5) Centar za nuklearnu medicine, KC Srbije


  Download in pdf format   Extended summary: Aim: The aim of this study was to evaluate the value of stimulated tireoglobulin (sTg) in patients with differentiated thyroid carcinoma (DTC) after the surgery and during the follow up period comparing the findings with the diagnostic 131I-whole body scan (DxWBS), posttherapy 131I- scan (TxWBS) and clinical findings. Patients and methods: A retrospective review comprised 164 DxWBS of 93 patients of whom 40 patients had only postsurgical scan while in others control DxWBSs were included as well. Scan results were considered positive if any focal uptake in the neck or elsewhere was visible and negative if the physiological radioiodine accumulation persisted. Stimulated Tg is considered positive if higher than 2ng/ml. Results: Negative value of sTg was detected in 56 cases with negative DxWBS scan results and positive sTg was concordant with higher values of sTg in 78 cases. Overall concordant findings were detected in 82% of cases. Discordant findings were detected in 30 cases (18%) of which in 20 (12%) DxWBS scan was positive, while in 10 (6%) cases DxWBS scan was negative and sTg positive. All the patients with discordant findings received radioidine ablation/therapy. Posttherapy whole body scan was concordant with the results of DxWBS in 20 patients with positive DxWBS and negative sTG and in 3 patients with negative DxWBS and positive sTG. However, negative TxWBS scan result was found in 7 of 10 patients with negative DxWBS and positive sTg. Conclusion: Our results showed that stimulated Tg cannot safely be used as a single marker for assessment of residual and recurrent disease in some patients with DTC. The results suggest that both DxWBS and sTg are of immense importance in a diagnostic algorithm in patients with DTC during different treatment phases.
Key words: whole body scan, thyreoglobulin, differentiated thyroid carcinoma

Napomena: kompletan tekst rada na srpskom jeziku
Note: full text in Serbian
      Corresponding Address:
Marina Vlajković,
Centar za nuklearnu medicinu, Klinički Centar Niš, Bul. dr Zorana Đinđića 48; 18 000 Niš, Srbija
Paper received: 31.7.2014
Paper accepted: 1.8.2014
Paper Internet issues: 17.11.2014
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Timočki medicinski glasnik, Zdravstveni centar Zaječar
Journal of Regional section of Serbian medical association in Zajecar
Rasadnička bb, 19000 Zaječar, Srbija

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