Journal of Regional Section of Serbian Medical Association in Zajecar

Year 2006     Volumen 31     No 4
Home ] Gore/Up ]<<< ] >>> ]
UDK: 618.146-006.6-036 ISSN 0350-2899 31 (2006) 4 p. 171-175
   
Original paper

Prognostic factors of Cervical Cancer

Dragan Perišić (1), Biljana Vukašinović (1), Slavka Đorđević (1), Dragoslav Kalinović (2)
(1) Zdravstveni centar Gornji Milanovac, (2) Zdravstveni centar Zaječar

 
 

 

 
  Summary:
Cervical cancer is one of the most frequent and most malignant tumours in females. The objective was to investigate the importance of individual prognostic factors in staging, the choice of treatment, the estimate of relapses and metastases as well as in the forecast of surviving period. During the research we used the data of 73 patients, of which 32 patients had the early cervical cancer, while the second group included 41 patients with already developed cervical cancer. The research was done at the Oncology Clinic and the Gynaecology Department of the Health Care Centre Gornji Milanovac and the research period covered the beginning of 1999 to the end of 2003. The research and statistical analysis confirmed that the negative prognostic factor in cervical cancer was the following: high FIGO stage, younger patients, larger tumours with deeper penetration of malignant cells in stroma and with lymphovascular invasion, tumours spreading over parametria and lymph glands, histopathological adenocarcinoma, G3 histological stage and early occurrence of relapses and metastases. Today timely detection of the malignancy in the early stages is most important in order to provide the optimal therapy. Patients with more negative prognostic factors need to be followed continually and adequate multimodal treatment is needed immediately after relapses.
Key words: Cervical cancer, prognostic factors, treatment, surviving period.

Napomena
: kompletan tekst rada na srpskom jeziku
Note: full text in Serbian
 
 
 

REFERENCES

  1. Landis SH, Murray T, Bolden S, and Wingo PA. Cancer statistics, 1999. CA Cancer J Clin 1999; 49: 8-31.
  2. Burger MPM, Hollema H, Pieters WJLM, Schröder FP, and Quint WGV. Epidemiological evidence of cervical intraepithelial neoplasia without the presence of human papillomavirus. Br J Cancer 1996; 73: 831-6.
  3. Averette HE, Nguyen HN, Donato DM, et al. Radical hysterectomy for invasive cervical cancer: a 25-year prospective experience with the Miami technique. Cancer 1993;71:1422.
  4. Lanciano RM, Won M, Hanks GE. A reappraisal of the International Federation of Gynecology and Obstetrics staging system for cervical cancer. Cancer 1992;69:482.
  5. Spanos WJ, King A, Keeney E, Wagner R, Slater JM. Age as a prognostic factor in carcinoma of the cervix. Gynecol Oncol 1989;35:66.
  6. Alvarez RD, Potter ME, Soong SJ, et al. Rationale for using pathologic tumor dimensions and nodal status to subclassify surgically treated stage IB cervical cancer patients. Gynecol Oncol 1991;43:108.
  7. Kovalic JJ, Perez CA, Grigsby PW, Lockett MA. The effect ovolume of disease in patients with carcinoma of the uterine cervix. Int J Radiat Oncol Biol Phys 1991;21:905.
  8. Kjorstad KE, Kjolvenstvedt A, Strickert T. The value of complete lymphadenectomy in radical treatment of cancer of the cervix, stage IB. Cancer 1984;54:2215.
  9. Boyce JG, Fruchter RG, Nicastri AD, et all. Vascular invasion in stage I carcinoma of the cervix. Cancer 1984;53:1175.
  10. Grugsby PW, Perez CA, Kuske RR, et al. Adenocarcinoma of the uterine cervix: lack of evidence for a poor prognosis. Radiother On 1988;12:289.
 
  Corresponding Address:
Dragan Perišić
Miloša Velikog br. 33, 32300 Gornji Milanovac
tel 032 710- 338, fax 032 722 200
e- mail: perisic@Eunet.yu

Paper received: 27.07.2006.
Paper accepted: 27.08.2006.
Published online: 31.01.2007.
 
Home ] Gore/Up ]<<< ] >>> ]
Infotrend Crea(c)tive Design